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Metabotropic glutamate receptor 5 in bulimia nervosa.

ABSTRACT: Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 matched controls. We measured mGlu5 distribution volume ratio (DVR) with positron emission tomography (PET) using [11?C]ABP688. In BN mGlu5 DVR was higher in the anterior cingulate cortex (ACC), subgenual prefrontal cortex, and straight gyrus (p?

SUBMITTER: Mihov Y

PROVIDER: S-EPMC7156702 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Metabotropic glutamate receptor 5 in bulimia nervosa.

Mihov Yoan Y Treyer Valerie V Akkus Funda F Toman Erika E Milos Gabriella G Ametamey Simon M SM Johayem Anass A Hasler Gregor G

Scientific reports 20200414 1

Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 matched controls. We measured mGlu5 distribution volume ratio (DVR) with positron emission tomography (PET) using [11 C]ABP688. In BN mGlu5 DVR was higher in ...[more]

PMID: 32286451

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