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Multi-Omics Analysis Reveals the Pan-Cancer Landscape of Bone Morphogenetic Proteins.

ABSTRACT: BACKGROUND Bone morphogenetic proteins (BMPs) are widely involved in cancer development. However, a wealth of conflicting data raises the question of whether BMPs serve as oncogenes or as cancer suppressors. MATERIAL AND METHODS By integrating multi-omics data across cancers, we comprehensively analyzed the genomic and pharmacogenomic landscape of BMP genes across cancers. RESULTS Surprisingly, our data indicate that BMPs are globally downregulated in cancers. Further genetics and epigenetics analyses show that this abnormal expression is driven by copy number variations, especially heterozygous amplification. We next assessed the BMP-associated pathways and demonstrated that they suppress cell cycle and estrogen hormone pathways. Bone morphogenetic protein interacts with 58 compounds, and their dysfunction can induce drug sensitivity. CONCLUSIONS Our results define the landscape of the BMP family at a systems level and open potential therapeutic opportunities for cancer patients.

SUBMITTER: Luo WL

PROVIDER: S-EPMC7156877 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Multi-Omics Analysis Reveals the Pan-Cancer Landscape of Bone Morphogenetic Proteins.

Luo Wen-Li WL Luo Ming-Xing MX He Rong-Zhen RZ Ying Lv-Fang LF Luo Jian J

Medical science monitor : international medical journal of experimental and clinical research 20200405

BACKGROUND Bone morphogenetic proteins (BMPs) are widely involved in cancer development. However, a wealth of conflicting data raises the question of whether BMPs serve as oncogenes or as cancer suppressors. MATERIAL AND METHODS By integrating multi-omics data across cancers, we comprehensively analyzed the genomic and pharmacogenomic landscape of BMP genes across cancers. RESULTS Surprisingly, our data indicate that BMPs are globally downregulated in cancers. Further genetics and epigenetics an ...[more]

PMID: 32248202

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Multi-Omics Analysis Reveals the Pan-Cancer Landscape of Bone Morphogenetic Proteins.

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Multi-Omics Analysis Reveals the Pan-Cancer Landscape of Bone Morphogenetic Proteins.

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