Ontology highlight
ABSTRACT: Background
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown.Methods
The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records.Results
The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death.Conclusion
NT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19.Trial registration
ClinicalTrials, NCT04292964. Registered 03 March 2020.
SUBMITTER: Gao L
PROVIDER: S-EPMC7156898 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Gao Lei L Jiang Dan D Wen Xue-Song XS Cheng Xiao-Cheng XC Sun Min M He Bin B You Lin-Na LN Lei Peng P Tan Xiao-Wei XW Qin Shu S Cai Guo-Qiang GQ Zhang Dong-Ying DY
Respiratory research 20200415 1
<h4>Background</h4>The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown.<h4>Methods</h4>The study initially enrolled 102 patients with ...[more]