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Prognostic value of NT-proBNP in patients with severe COVID-19.


ABSTRACT:

Background

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown.

Methods

The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records.

Results

The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death.

Conclusion

NT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19.

Trial registration

ClinicalTrials, NCT04292964. Registered 03 March 2020.

SUBMITTER: Gao L 

PROVIDER: S-EPMC7156898 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Publications

Prognostic value of NT-proBNP in patients with severe COVID-19.

Gao Lei L   Jiang Dan D   Wen Xue-Song XS   Cheng Xiao-Cheng XC   Sun Min M   He Bin B   You Lin-Na LN   Lei Peng P   Tan Xiao-Wei XW   Qin Shu S   Cai Guo-Qiang GQ   Zhang Dong-Ying DY  

Respiratory research 20200415 1


<h4>Background</h4>The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown.<h4>Methods</h4>The study initially enrolled 102 patients with  ...[more]

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