A biophysical perspective on receptor-mediated virus entry with a focus on HIV.

ABSTRACT: As part of their entry and infection strategy, viruses interact with specific receptor molecules expressed on the surface of target cells. The efficiency and kinetics of the virus-receptor interactions required for a virus to productively infect a cell is determined by the biophysical properties of the receptors, which are in turn influenced by the receptors' plasma membrane (PM) environments. Currently, little is known about the biophysical properties of these receptor molecules or their engagement during virus binding and entry. Here we review virus-receptor interactions focusing on the human immunodeficiency virus type 1 (HIV), the etiological agent of acquired immunodeficiency syndrome (AIDS), as a model system. HIV is one of the best characterised enveloped viruses, with the identity,

SUBMITTER: Llorente Garcia I 

PROVIDER: S-EPMC7156917 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature