Association of SNPs in CDKN2A (P14ARF) Tumour Suppressor Gene With Endometrial Cancer in Postmenopausal Women.
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ABSTRACT:
SUBMITTER: Wujcicka W
PROVIDER: S-EPMC7157895 | biostudies-literature | 2020 Mar-Apr
REPOSITORIES: biostudies-literature
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Association of SNPs in CDKN2A (P14ARF) Tumour Suppressor Gene With Endometrial Cancer in Postmenopausal Women.
Wujcicka Wioletta W Zajac Agnieszka A Szyllo Krzysztof K Smolarz Beata B Romanowicz Hanna H Stachowiak Grzegorz G
In vivo (Athens, Greece) 20200301 2
<h4>Background/aim</h4>This research was aimed to evaluate the association between three selected single nucleotide polymorphisms (SNPs) within the CDKN2A (P14ARF) tumour suppressor gene and the incidence of endometrial cancer (EC) in postmenopausal women.<h4>Patients and methods</h4>The study included 194 postmenopausal women; 144 with EC and 50 non-cancer controls. Genotypes in P14ARF rs3088440, rs3731217 and rs3731245 polymorphisms were assayed using PCR-RFLP and confirmed by sequencing.<h4>R ...[more]
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