Ontology highlight
ABSTRACT:
SUBMITTER: Ding J
PROVIDER: S-EPMC7158205 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Ding Junjie J Thuy Thuong Thuong Nguyen N Pham Toi Van TV Heemskerk Dorothee D Pouplin Thomas T Tran Chau Thi Hong CTH Nguyen Mai Thi Hoang MTH Nguyen Phu Hoan PH Phan Loc Phu LP Nguyen Chau Van Vinh CVV Thwaites Guy G Tarning Joel J
Clinical pharmacology and therapeutics 20200229 4
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure-response relationships that might explain the trial re ...[more]