Dataset Information
Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.
Ontology highlight
ABSTRACT: Background
Due to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of adverse outcomes compared to nontransplant controls. Understanding the burden of disease in transplant recipients may inform treatment decisions of people whose native kidneys are failing and may be eligible for a transplant.Objective
To compare mortality and morbidity in kidney transplant recipients with a failing graft to matched nontransplant controls.Design
Retrospective cohort study.Setting
Alberta, Canada.Patients
Kidney transplant recipients with a failing graft were identified as having at least 2 estimated glomerular filtration rate (eGFR) measurements between 15-30 mL/min/1.73 m2 (90-365 days apart). We also identified nontransplant controls with a similar degree of kidney dysfunction.Measurements
Mortality and hospitalization.Methods
We propensity-score matched 520 kidney transplant recipients with a failing graft to 520 nontransplant controls.Results
The median age of the matched cohort was 57 years and 40% were women. Compared to matched nontransplant controls, recipients with a failing graft had a higher hazard of death (hazard ratio, 1.54; 95% confidence interval [CI], 1.28-1.85; p < .001) and a higher rate of all-cause hospitalization (rate ratio, 1.67; 95% CI, 1.42-1.97; p < .001). Kidney transplant recipients also had a higher rate of several cause-specific hospitalizations including genitourinary, cardiovascular, and infectious causes.Limitations
Observational design with the risk of residual confounding.Conclusions
A failing kidney transplant is associated with an increased burden of mortality and morbidity beyond chronic kidney disease. This information may assist the discussion of prognosis in kidney transplant recipients with a failing graft and the design of strategies to minimize risks.
SUBMITTER: Lam NN
PROVIDER: S-EPMC7158256 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.
Canadian journal of kidney health and disease 20200414
<h4>Background</h4>Due to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of adverse outcomes compared to nontransplant controls. Understanding the burden of disease in transplant recipients may inform treatment decisions of people whose native kidneys are failing and may be eligible for a transplant.<h4>Objective</h4>To compare mortality and morbidity in kidney transplant recipients with a failing graft to ...[more]