Dataset Information

Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.

ABSTRACT:

Background

Due to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of adverse outcomes compared to nontransplant controls. Understanding the burden of disease in transplant recipients may inform treatment decisions of people whose native kidneys are failing and may be eligible for a transplant.

Objective

To compare mortality and morbidity in kidney transplant recipients with a failing graft to matched nontransplant controls.

Design

Retrospective cohort study.

Setting

Alberta, Canada.

Patients

Kidney transplant recipients with a failing graft were identified as having at least 2 estimated glomerular filtration rate (eGFR) measurements between 15-30 mL/min/1.73 m² (90-365 days apart). We also identified nontransplant controls with a similar degree of kidney dysfunction.

Measurements

Mortality and hospitalization.

Methods

We propensity-score matched 520 kidney transplant recipients with a failing graft to 520 nontransplant controls.

Results

The median age of the matched cohort was 57 years and 40% were women. Compared to matched nontransplant controls, recipients with a failing graft had a higher hazard of death (hazard ratio, 1.54; 95% confidence interval [CI], 1.28-1.85; p < .001) and a higher rate of all-cause hospitalization (rate ratio, 1.67; 95% CI, 1.42-1.97; p < .001). Kidney transplant recipients also had a higher rate of several cause-specific hospitalizations including genitourinary, cardiovascular, and infectious causes.

Limitations

Observational design with the risk of residual confounding.

Conclusions

A failing kidney transplant is associated with an increased burden of mortality and morbidity beyond chronic kidney disease. This information may assist the discussion of prognosis in kidney transplant recipients with a failing graft and the design of strategies to minimize risks.

SUBMITTER: Lam NN

PROVIDER: S-EPMC7158256 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.

Lam Ngan N NN Boyne Devon J DJ Quinn Robert R RR Austin Peter C PC Hemmelgarn Brenda R BR Campbell Patricia P Knoll Gregory A GA Tibbles Lee Anne LA Yilmaz Serdar S Quan Hude H Ravani Pietro P

Canadian journal of kidney health and disease 20200414

<h4>Background</h4>Due to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of adverse outcomes compared to nontransplant controls. Understanding the burden of disease in transplant recipients may inform treatment decisions of people whose native kidneys are failing and may be eligible for a transplant.<h4>Objective</h4>To compare mortality and morbidity in kidney transplant recipients with a failing graft to ...[more]

PMID: 32313663

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Dataset Information

Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.

Background

Objective

Design

Setting

Patients

Measurements

Methods

Results

Limitations

Conclusions

Publications

Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.

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