Ontology highlight
ABSTRACT:
SUBMITTER: Kuang Z
PROVIDER: S-EPMC7158748 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Kuang Zheng Z Wang Yuhao Y Li Yun Y Ye Cunqi C Ruhn Kelly A KA Behrendt Cassie L CL Olson Eric N EN Hooper Lora V LV
Science (New York, N.Y.) 20190901 6460
Circadian rhythmicity is a defining feature of mammalian metabolism that synchronizes metabolic processes to day-night light cycles. Here, we show that the intestinal microbiota programs diurnal metabolic rhythms in the mouse small intestine through histone deacetylase 3 (HDAC3). The microbiota induced expression of intestinal epithelial HDAC3, which was recruited rhythmically to chromatin, and produced synchronized diurnal oscillations in histone acetylation, metabolic gene expression, and nutr ...[more]