Project description:HPLC MS/MS confirmation of lipids found to be heterogeneously distributed between rested and sleep-deprived Drosophila melanogaster brain samples by MALDI MSI. Data belongs to publication "Kv Channels Integrate Sleep Pressure in a Voltage-Gated Lipid Peroxidation Memory"

2023-04-21 | MSV000091767 | MassIVE

Effect of Sleep Deprivation on the Whole Brain of Drosophila

Project description:To gain insight into the dynamic molecular processes that are altered during prolonged wakefulness and during sleep. We performed an RNA expression profiling study examining temporal changes in the brain of Drosophila in relationship to the duration of prior sleep or wakefulness. Our experimental design allowed us to determine whether genes identified as differentially regulated between sleep and wakefulness were up- or down-regulated in these states. Because stimulation of the experimental animal during the normal sleep period is used to prolong wakefulness in most experimental paradigms, the interpretation of the effects of prolonged wakefulness is confounded by the effect of the perturbation stimulus itself on the animal’s biology. We controlled for this effect in our experimental paradigm by examining gene expression changes in response to identical stimulation but during the animal’s normal wakefulness. The design of our study also allowed us to control for circadian variation in gene expression, since we compared sleeping and sleep deprived flies at the same diurnal time. Keywords: sleep deprivation, time course, stress response

2006-02-27 | GSE4174 | GEO

Effect of sleep deprivation on non-small cell lung cancer metastasis

Project description:Recent research has shed light on the influence of sleep deprivation on tumor progression, particularly in non-small cell lung cancer (NSCLC), although the precise underlying mechanisms remain poorly understood. Several studies have highlighted alterations in immune cell dynamics and intercellular communication as key consequences of sleep deprivation. Moreover, heightened sympathetic nervous system activity has been implicated in this context. To explore these phenomena further, transcriptome sequencing was conducted in tumor-bearing mice subjected to normal sleep conditions versus sleep deprivation. This approach aimed to delineate the molecular mechanisms linking sleep deprivation to NSCLC progression.

2025-04-30 | GSE274724 | GEO

Sleep deprivation enhances inter-stimulus interval effect on vigilant attention performance.

Project description: Not available

| S-EPMC6289239 | biostudies-literature

Sleep deprivation and the brain

Project description:This SuperSeries is composed of the SubSeries listed below.

2007-12-07 | GSE9444 | GEO

Clarifying the Effect of Test Speededness.

Project description: Not available

| S-EPMC6745631 | biostudies-literature

Sleep Deprivation and Recovery Sleep for 7 Regions of Mouse Brain.

Project description:Analysis of the effects of sleep deprivation, recovery sleep, and three time-of-day controls on seven brain regions laser microdissected from mouse brain. The regions include the locus coeruleus, suprachiasmatic nucleus, hypocretin area, tuberomammillary nucleus, orbital cortex, posteromedial cortical amygdala, and entorhinal cortex. In this study, 7 brain regions were collected by laser microdissection from brain tissue of mice from 5 different treatment groups and used for microarray experiments. Four biological replicates were generated for each regionxcondition. Conditions are: SD, sleep deprivation for 6 hours from ZT0 - 6; SDC, time-of-day control for SD at ZT6; RS, recovery sleep for 4 hours following SD; RSC, time-of-day control for RS at ZT10; W, spontaneous waking at ZT18.

2010-08-16 | E-GEOD-23628 | biostudies-arrayexpress

LK immunophenotype cells after sleep deprivation.

Project description:To investigate the effects of sleep deprivation on hematopoietic stem cells in the bone marrow and the changes in the bone marrow microenvironment, we constructed a single-cell atlas.

2024-12-01 | GSE280145 | GEO

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