A? deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Mattsson-Carlgren N
PROVIDER: S-EPMC7159908 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease.
Mattsson-Carlgren Niklas N Andersson Emelie E Janelidze Shorena S Ossenkoppele Rik R Insel Philip P Strandberg Olof O Zetterberg Henrik H Rosen Howard J HJ Rabinovici Gil G Chai Xiyun X Blennow Kaj K Dage Jeffrey L JL Stomrud Erik E Smith Ruben R Palmqvist Sebastian S Hansson Oskar O
Science advances 20200415 16
The links between β-amyloid (Aβ) and tau in Alzheimer's disease are unclear. Cognitively unimpaired persons with signs of Aβ pathology had increased cerebrospinal fluid (CSF) phosphorylated tau (P-tau181 and P-tau217) and total-tau (T-tau), which increased over time, despite no detection of insoluble tau aggregates [normal Tau positron emission tomography (PET)]. CSF P-tau and T-tau started to increase before the threshold for Amyloid PET positivity, while Tau PET started to increase after Amylo ...[more]
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