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Prognostic value of sarcopenia in patients with colorectal liver metastases undergoing hepatic resection.

ABSTRACT: The prognostic significance of sarcopenia has been widely studied in different cancer patients. This study aimed to analyze the influence of sarcopenia on long-term survival in patients with colorectal liver metastasis (CRLM) undergoing hepatic resection. A retrospective analysis of 182 patients undergoing hepatic resection for CRLM was performed. Sarcopenia was determinedusing the Hounsfield unit average calculation (HUAC), a measure of muscle quality-muscledensity at preoperative abdominal computed tomography scans. Sarcopenia was defined as an HUAC score of less than 22 HU calculated using receiver operating characteristic analysis. The prognostic relevance of clinical variables and overall survival (OS) and recurrence-free survival (RFS) was evaluated. Patients with sarcopenia were older (p?3) (hazard ratio (HR) 2.736; 95% confidence interval (CI), 1.631-4.589; p?3) (HR 1.750; 95% CI, 1.066-2.872; p?=?0.027), high aspartate aminotransferase level (HR 1.024; 95% CI, 1.003-1.046; p?=?0.025) and male gender (HR 1.688; 95% CI, 1.036-2.748; p?=?0.035) were independent factors of RFS. In conclusion, despite no significance in whole cohort, sarcopenia was predictive of worse OS in patients with multiple CRLM after partial hepatectomy.

SUBMITTER: Liu YW

PROVIDER: S-EPMC7160152 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Prognostic value of sarcopenia in patients with colorectal liver metastases undergoing hepatic resection.

Liu Yueh-Wei YW Lu Chien-Chang CC Chang Ching-Di CD Lee Ko-Chao KC Chen Hong Hwa HH Yeh Wen Shuo WS Hu Wang-Hseng WH Tsai Kai-Lung KL Yeh Cheng-Hsi CH Wee Sin-Yong SY Yin Shin-Min SM Wang Chih-Chi CC Hung Chao-Hung CH

Scientific reports 20200415 1

The prognostic significance of sarcopenia has been widely studied in different cancer patients. This study aimed to analyze the influence of sarcopenia on long-term survival in patients with colorectal liver metastasis (CRLM) undergoing hepatic resection. A retrospective analysis of 182 patients undergoing hepatic resection for CRLM was performed. Sarcopenia was determinedusing the Hounsfield unit average calculation (HUAC), a measure of muscle quality-muscledensity at preoperative abdominal com ...[more]

PMID: 32296122

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Project description:UnlabelledIntegrins are cell surface adhesion molecules (CAM) that regulate via intercellular and cell-matrix signaling various cellular processes including wound healing, cell differentiation, division, growth, migration and metastatic dissemination. Although a correlation between carcinogenesis and changes in integrin expression, especially ?1 integrin, has been reported, its role in colorectal liver metastases remains unclear. This study aimed to evaluate the expression of ?1 integrin in colorectal liver metastases and to correlate the pattern of expression with clinicopathological features and to investigate the putative role of ?1 integrin expression on survival of these patients.MethodsFormalin-fixed, paraffin-embedded (FFPE) tumor samples of 81 patients who were operated because of colorectal liver metastases without any neoadjuvant therapy were obtained and stained with hematoxylin and eosin (H & E). An immunohistochemical examination was performed using Dako, Peroxidase/DAB kit and a primary monoclonal ?1 integrin (CD29, fibronectin receptor subunit beta; ab3167, Abcam plc). ?1 integrin expression was evaluated according to the immunoreactive score of Remmele and Stegner and was related with clinicopathological features of prognostic significance and with disease-free and overall survival as well. Statistical analysis was performed using SPSS version 21.0.Results?1 integrin was overexpressed in tumor cells in 37 (48%) patients and in stromal cell in 27 (33%) patients. The ?1 expression was not statistically correlated with clinicopathological features of the primary tumors but it was statistically correlated (p=0.03) with the histological grading of liver metastases. Kaplan-Meier survival analysis showed that there is a tendency but no statistically significant correlation in disease-free and overall survival.ConclusionConsidering that expression of ?1 integrin in colorectal liver metastases remains controversial, specially its relation with survival of patients, we showed that the ?1 expression represents a reliable prognostic factor regarding the grading of liver metastases of CRC and our findings imply that ?1 integrin expression profiles may have further potential in identifying the stage of colorectal liver metastases and being a marker of prognosis in these patients.

Dataset Information

Prognostic value of sarcopenia in patients with colorectal liver metastases undergoing hepatic resection.

Publications

Prognostic value of sarcopenia in patients with colorectal liver metastases undergoing hepatic resection.

Similar Datasets

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