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Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells.

ABSTRACT: The human translation machinery includes three types of supramolecular complexes involved in elongation of the polypeptide chain: the ribosome, complex of elongation factors eEF1B and multienzyme aminoacyl-tRNA synthetase complex. Of the above, eEF1B is the least investigated assembly. Recently, a number of studies provided some insights into the structure of different eEF1B subunits and changes in their expression in cancer and other diseases. There is increasing agreement that possible disease-related functions of eEF1B are not necessarily related to its role in translation. This mini-review focuses on structural and functional features of the eEF1B complex while paying special attention to possible non-canonical functions of its subunits in cancer cells.

SUBMITTER: Negrutskii B

PROVIDER: S-EPMC7160314 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells.

Negrutskii Boris B

Frontiers in molecular biosciences 20200409

The human translation machinery includes three types of supramolecular complexes involved in elongation of the polypeptide chain: the ribosome, complex of elongation factors eEF1B and multienzyme aminoacyl-tRNA synthetase complex. Of the above, eEF1B is the least investigated assembly. Recently, a number of studies provided some insights into the structure of different eEF1B subunits and changes in their expression in cancer and other diseases. There is increasing agreement that possible disease ...[more]

PMID: 32328499

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