Ontology highlight
ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC7161709 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Zhang Baoyuan B Lyu Junfang J Yang Eun Ju EJ Liu Yifan Y Wu Changjie C Pardeshi Lakhansing L Tan Kaeling K Chen Qiang Q Xu Xiaoling X Deng Chu-Xia CX Shim Joong Sup JS
Acta pharmaceutica Sinica. B 20190905 4
Breast cancer susceptibility gene 1 (<i>BRCA1</i>) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. In this study, we found that inhibition of the class I histone deacetylases (HDAC) exhibited synthetic lethality with BRCA1 deficiency in breast cancer cells. Transcriptome profiling and validation study sho ...[more]