Ontology highlight
ABSTRACT:
SUBMITTER: Christensen NR
PROVIDER: S-EPMC7161847 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Christensen Nikolaj R NR Čalyševa Jelena J Fernandes Eduardo F A EFA Lüchow Susanne S Clemmensen Louise S LS Haugaard-Kedström Linda M LM Strømgaard Kristian K
Advanced therapeutics 20190424 7
Protein-protein interactions within protein networks shape the human interactome, which often is promoted by specialized protein interaction modules, such as the postsynaptic density-95 (PSD-95), discs-large, zona occludens 1 (ZO-1) (PDZ) domains. PDZ domains play a role in several cellular functions, from cell-cell communication and polarization, to regulation of protein transport and protein metabolism. PDZ domain proteins are also crucial in the formation and stability of protein complexes, e ...[more]