Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma.
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ABSTRACT:
SUBMITTER: Swan D
PROVIDER: S-EPMC7162079 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma.
Swan Dawn D Gurney Mark M Krawczyk Janusz J Ryan Aideen E AE O'Dwyer Michael M
HemaSphere 20200403 2
The alkylating agent cyclophosphamide has been used in the treatment of multiple myeloma for over 60 years. At low doses, cyclophosphamide also has significant immunomodulatory activity, which can be used to modify the immunosuppressive tumor microenvironment in order to augment responses to existing therapies. Immune-mediated therapies are becoming more widespread in modern approaches to myeloma treatment. In this review, we discuss the effects cyclophosphamide has on the immune system, and how ...[more]
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