Ontology highlight
ABSTRACT:
SUBMITTER: Lone AG
PROVIDER: S-EPMC7162589 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lone Abdul G AG Bankhead Troy T
Cell reports 20200301 11
Arp is an immunogenic protein of the Lyme disease spirochete Borrelia burgdorferi and contributes to joint inflammation during infection. Despite Arp eliciting a strong humoral response, antibodies fail to clear the infection. Given previous evidence of immune avoidance mediated by the antigenically variable lipoprotein of B. burgdorferi, VlsE, we use passive immunization assays to examine whether VlsE protects the pathogen from anti-Arp antibodies. The results show that spirochetes are only abl ...[more]