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Translation and Validation of Chronic Otitis Media Benefit Inventory (COMBI) in Turkish Language.

ABSTRACT: Objective:The aim of this study was to translate the Chronic Otitis Media Benefit Inventory (COMBI) into Turkish and evaluate the questionnaire's reliability in assessing benefit outcomes in patients after ear surgery. Methods:A total of 30 patients with chronic otitis media who underwent ear surgery were asked to fill out the translated Turkish version of the COMBI questionnaire six months after their surgery twice, 10 days apart. The patients were divided into two groups in two different ways based on surgical and audiological outcomes. These were surgical success (SS), surgical failure (SF), audiological success (AS), audiological failure (AF) groups. Student's -t test was performed to show the differences in the COMBI scores of the groups. Cronbach's alpha value was calculated to test internal consistency, Pearson's correlation coefficient was measured to demonstrate test-retest reliability and factor analysis was run. Results:The average score of the SS group was 51.08 and significantly higher than the score of the SF group (42.40) (p=0.012). There was, however, no statistically significant difference between the average scores of the AS and the AF groups (p=0.330). A Cronbach's alpha value of 0.862 was found. Pearson's r value was calculated 0.810. Factor analysis showed that a three-factor solution explained the 70.2% of the variance. Conclusion:The Turkish version of the COMBI is a valid test with high test-retest reliability. It should be used with objective assessment tools for better understanding how patients benefit from the surgery.

SUBMITTER: Kara H

PROVIDER: S-EPMC7162599 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Translation and Validation of Chronic Otitis Media Benefit Inventory (COMBI) in Turkish Language.

Kara Hakan H Doruk Can C Çelik Mehmet M Polat Beldan B Topsakal Vedat V Orhan Kadir Serkan KS

Turkish archives of otorhinolaryngology 20190814 1

<h4>Objective</h4>The aim of this study was to translate the Chronic Otitis Media Benefit Inventory (COMBI) into Turkish and evaluate the questionnaire's reliability in assessing benefit outcomes in patients after ear surgery.<h4>Methods</h4>A total of 30 patients with chronic otitis media who underwent ear surgery were asked to fill out the translated Turkish version of the COMBI questionnaire six months after their surgery twice, 10 days apart. The patients were divided into two groups in two ...[more]

PMID: 32313891

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Project description:IntroductionMajor features of the pathogenesis in otitis media, the most common disease in childhood, include hyperplasia of the middle ear mucosa and infiltration by leukocytes, both of which typically resolve upon bacterial clearance via apoptosis. Activation of innate immune receptors during the inflammatory process leads to the activation of intracellular transcription factors (such as NF-κB, AP-1), which regulate both the inflammatory response and tissue growth. We investigated these leading signaling pathways in otitis media using mouse models, human samples, and human middle ear epithelial cell (HMEEC) lines for therapeutic immunomodulation.MethodsA stable otitis media model in wild-type mice and immunodeficient KO-mice, as well as human tissue samples from chronic otitis media, skin from the external auditory canal and middle ear mucosa removed from patients undergoing ear surgery, were studied. Gene and protein expression of innate immune signaling molecules were evaluated using microarray, qPCR and IHC. In situ apoptosis detection determined the apoptotic rate. The influence of bacterial infection on immunomodulating molecules (TNFα, MDP, Tri-DAP, SB203580, Cycloheximide) in HMEEC was evaluated. HMEEC cells were examined after bacterial stimulation/inhibition for gene expression and cellular growth.ResultsPersistent mucosal hyperplasia of the middle ear mucosa in chronic otitis media resulted from gene and protein expression of inflammatory and apoptotic genes, including NODs, TNFα, Casp3 and cleaved Casp3. In clinical chronic middle ear samples, these molecules were modulated after a specific stimulation. They also induced a hyposensitive response after bacterial/NOD-/TLR-pathway double stimulation of HMEEC cells in vitro. Hence, they might be suitable targets for immunological therapeutic approaches.ConclusionUncontrolled middle ear mucosal hyperplasia is triggered by TLRs/NLRs immunoreceptor activation of downstream inflammatory and apoptotic molecules.

Dataset Information

Translation and Validation of Chronic Otitis Media Benefit Inventory (COMBI) in Turkish Language.

Publications

Translation and Validation of Chronic Otitis Media Benefit Inventory (COMBI) in Turkish Language.

Similar Datasets

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