Prefrontal cortical activation during working memory task anticipation contributes to discrimination between bipolar and unipolar depression.

ABSTRACT: Distinguishing bipolar disorder (BD) from major depressive disorder (MDD) is clinically challenging, especially during depressive episodes. While both groups are characterized by aberrant working memory and anticipatory processing, the role of these processes in discriminating BD from MDD remains unexplored. In this study, we examine how brain activation corresponding to anticipation of and performance on easy vs. difficult working memory tasks with emotional stimuli contributes to discrimination among BD, MDD, and healthy controls (HC). Depressed individuals with BD (n = 18), MDD (n = 23), and HC (n = 23) were scanned while performing a working memory task in which they had to first anticipate performance on 1-back (easy) or 2-back (difficult) tasks with happy, fearful, or neutral faces,

SUBMITTER: Manelis A 

PROVIDER: S-EPMC7162920 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature