Ontology highlight
ABSTRACT:
SUBMITTER: Repellin CE
PROVIDER: S-EPMC7162992 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Repellin Claire E CE Ganesan Priya P Alcudia Javier F JF Lakshmireddy Haritha K Duggireddy HKD Patel Puja P Beviglia Lucia L Javitz Harold S HS Sambucetti Lidia L Bhatnagar Parijat P
Advanced biosystems 20191129 1
A set of genetically engineered isogenic cell lines is developed to express either folate receptor alpha or mesothelin, and a control cell line negative for both antigens. These cell lines also express fluorescent and bioluminescent reporter transgenes. The cell lines are used to authenticate specificity and function of a T-cell biofactory, a living vector that is developed to express proportionate amounts of engineered proteins upon engaging with disease cells through their specific antigenic b ...[more]