Dataset Information

Distribution of urinary gamma-glutamyltransferase activity in 40- to 74-year-old Japanese women.

ABSTRACT: Urinary gamma-glutamyltransferase (u-?GT) concentration (U/L) and excretion (urinary creatinine-corrected u-?GT; u-?GT/u-Cre, U/g creatinine) are useful markers for kidney disease. However, there is limited information available on u-?GT and u-?GT/u-Cre distribution in the elderly Japanese population. In this study, we investigated the distribution of u-?GT and u-?GT/u-Cre in 113 Japanese women aged 40-74 years. The u-?GT was assessed from spot urine samples (collected from 09:00 to 14:00) spectrophotometrically according to the Japan Society of Clinical Chemistry reference measurement procedure using l-?-glutamyl-3-carboxy-4-nitroanilide as the substrate. The u-Cre was measured enzymatically using creatininase, creatinase, sarcosine oxidase, and peroxidase. None of the participants was diagnosed with any kidney disease. Median u-?GT and u-?GT/u-Cre values (central 95% interval values) were 29.7 (5.3-144.0) U/L and 57.9 (32.9-122.7) U/g creatinine, respectively. The distribution of u-?GT tended to decline with age. There was a statistically significant difference in the u-?GT value between the 40-59- and 60-74-year-old groups. In contrast, there was no significant difference in the u-?GT/u-Cre between each age group. The u-Cre level also declined with age. It is suggested that the decline of u-?GT with aging would be masked by the u-Cre correction.

SUBMITTER: Hata A

PROVIDER: S-EPMC7163312 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Distribution of urinary gamma-glutamyltransferase activity in 40- to 74-year-old Japanese women.

Hata Akihisa A Miyauchi Maki M Suzuki Yoshio Y Otomo Yuki Y Fujitani Noboru N

Practical laboratory medicine 20200405

Urinary gamma-glutamyltransferase (u-γGT) concentration (U/L) and excretion (urinary creatinine-corrected u-γGT; u-γGT/u-Cre, U/g creatinine) are useful markers for kidney disease. However, there is limited information available on u-γGT and u-γGT/u-Cre distribution in the elderly Japanese population. In this study, we investigated the distribution of u-γGT and u-γGT/u-Cre in 113 Japanese women aged 40-74 years. The u-γGT was assessed from spot urine samples (collected from 09:00 to 14:00) spect ...[more]

PMID: 32322645

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Project description:BackgroundFalls are important causes of injury and mortality in older people, and associated medical costs can be enormous. Physical activity (PA) is a potential preventive factor for falls. However, few studies have examined the effect of different types of PA on fall prevention. This study aimed to evaluate the association between PA levels and the incidence of recurrent falls by type of PA in middle-aged and older people.MethodsThis cohort study targeted 7,561 community-dwelling individuals aged 40-74 years who did not experience recurrent falls in the year before baseline. Information on PA levels, demographics, body size, lifestyle, and fall/disease history was obtained using a self-administered questionnaire in the baseline survey. Levels of total PA, leisure-time PA, and non-leisure-time PA (occupation, commuting, and housework) were estimated using metabolic equivalent (MET) scores (MET-h/day; hours spent on a given activity per day multiplied by its MET intensity). PA levels were categorized into four groups. Falls were recorded as none, once, or twice or more (recurrent falls). The outcome of the study was the incidence of recurrent falls in the past year before a survey conducted 5 years after the baseline survey. Logistic regression analyses were performed to calculate odds ratios for recurrent falls.ResultsHigher total PA and non-leisure-time PA levels were associated with a higher risk of recurrent falls (P for trend = 0.0002 and 0.0001, respectively), with the highest total PA and non-leisure-time PA groups having a significantly higher adjusted OR (1.96 [95%CI:1.33-2.88] and 2.15 [95%CI:1.48-3.14], respectively) relative to the lowest group (reference). As for leisure-time PA, the medium group had a significantly lower adjusted OR (0.70 [95%CI:0.49-0.99]) relative to the reference group. By sex, the adjusted OR in the medium leisure-time PA group was significantly lower relative to the reference group in women (0.50 [95%CI: 0.29-0.85]) but not in men.ConclusionsMedium level leisure-time PA reduces the risk of recurrent falls in middle-aged and older people, whereas higher level non-leisure-time PA is associated with a higher risk of recurrent falls.

Dataset Information

Distribution of urinary gamma-glutamyltransferase activity in 40- to 74-year-old Japanese women.

Publications

Distribution of urinary gamma-glutamyltransferase activity in 40- to 74-year-old Japanese women.

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