RNA-virus proteases counteracting host innate immunity.
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ABSTRACT:
SUBMITTER: Lei J
PROVIDER: S-EPMC7163997 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
RNA-virus proteases counteracting host innate immunity.
Lei Jian J Lei Jian J Hilgenfeld Rolf R
FEBS letters 20170915 20
Virus invasion triggers host immune responses, in particular, innate immune responses. Pathogen-associated molecular patterns of viruses (such as dsRNA, ssRNA, or viral proteins) released during virus replication are detected by the corresponding pattern-recognition receptors of the host, and innate immune responses are induced. Through production of type-I and type-III interferons as well as various other cytokines, the host innate immune system forms the frontline to protect host cells and inh ...[more]
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