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Epidemiology of rheumatoid arthritis in sub-Saharan Africa: a systematic review and meta-analysis protocol.


ABSTRACT: BACKGROUND:So far, only one meta-analysis has estimated the prevalence of rheumatoid arthritis (RA) in Africa. Out of 10 studies included in that meta-analysis, nine came from sub-Saharan African countries and had been published between 1968 and 1988. We will conduct a new systematic review and meta-analysis to update their estimates and provide more consistent prevalence data on RA in sub-Saharan Africa. METHODS:We will comprehensively search electronic databases to select observational studies addressing RA in sub-Saharan Africa and published as from 1 January 2000: PubMed, EMBASE, African Journals Online, Web of Science, and Global Index Medicus. Summary estimates will be derived through random-effects meta-analysis whenever possible. Alternatively, estimates will be reported through narrative synthesis when the random-effects meta-analysis will be impossible. The risk of bias will be assessed using standard methods. DISCUSSION:This systematic review and meta-analysis shall quantify the magnitude of RA morbidity and mortality in sub-Saharan Africa. Results from this review will be disseminated in peer-reviewed journals, conferences and on social media platforms. SYSTEMATIC REVIEW REGISTRATION:PROSPERO CRD42020153483.

SUBMITTER: Essouma M 

PROVIDER: S-EPMC7164226 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Epidemiology of rheumatoid arthritis in sub-Saharan Africa: a systematic review and meta-analysis protocol.

Essouma Mickael M   Nkeck Jan René JR   Endomba Francky Teddy FT   Bigna Jean Joel JJ   Ralandison Stéphane S  

Systematic reviews 20200417 1


<h4>Background</h4>So far, only one meta-analysis has estimated the prevalence of rheumatoid arthritis (RA) in Africa. Out of 10 studies included in that meta-analysis, nine came from sub-Saharan African countries and had been published between 1968 and 1988. We will conduct a new systematic review and meta-analysis to update their estimates and provide more consistent prevalence data on RA in sub-Saharan Africa.<h4>Methods</h4>We will comprehensively search electronic databases to select observ  ...[more]

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