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Exosomal miRNAs in tumor microenvironment.

ABSTRACT: Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids and nucleic acids. Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development. Tumor-derived exosomal miRNAs induce matrix reprogramming in TME, creating a microenvironment that is conducive to tumor growth, metastasis, immune escape and chemotherapy resistance. In this review, we updated the role of exosomal miRNAs in the process of TME reshaping.

SUBMITTER: Tan S

PROVIDER: S-EPMC7164281 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Exosomal miRNAs in tumor microenvironment.

Tan Shiming S Xia Longzheng L Yi Pin P Han Yaqian Y Tang Lu L Pan Qing Q Tian Yutong Y Rao Shan S Oyang Linda L Liang Jiaxin J Lin Jinguan J Su Min M Shi Yingrui Y Cao Deliang D Zhou Yujuan Y Liao Qianjin Q

Journal of experimental & clinical cancer research : CR 20200416 1

Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids and nucleic acids. Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development. Tumor-derived exosomal ...[more]

PMID: 32299469

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