Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC7165047 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Liu Xinjian X Hu Mengjie M Liu Pei P Jiao Meng M Zhou Min M Lee Andrew K AK Li Fang F Li Chuan-Yuan CY
Cancer research 20200214 8
The role of the ataxia-telangiectasia-mutated (ATM) gene in human malignancies, especially in solid tumors, remains poorly understood. In the present study, we explored the involvement of ATM in transforming primary human cells into cancer stem cells. We show that ATM plays an unexpected role in facilitating oncogene-induced malignant transformation through transcriptional reprogramming. Exogenous expression of an oncogene cocktail induced a significant amount of DNA double-strand breaks in huma ...[more]