Evaluation of the Host Genetic Effects of Tuberculosis-Associated Variants Among Patients With Type 1 and Type 2 Diabetes Mellitus.

ABSTRACT:

Background

Understanding the link between tuberculosis (TB) and diabetes is increasingly important as public health responds to the growing global burden of noncommunicable diseases. Genetic association studies have identified numerous host genetic variants linked to TB; however, potential host genetic mechanisms linking TB and diabetes remain unexplored.

Methods

We used genetic and phenotypic data from the UK Biobank to evaluate the association of 6 previously reported TB-related host genetic variants (genome-wide significant associations from published studies) with diabetes. The study included 409692 adults of European ancestry including 2177 with type 1 diabetes mellitus (T1DM) and 13976 with type 2 diabetes mellitus (T2DM), defined by ICD-10 diag

SUBMITTER: Zhong H 

PROVIDER: S-EPMC7166116 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature