Dataset Information

Pyrexia in juvenile dogs: a review of 140 referred cases.

ABSTRACT:

Objectives

To describe the presentation, influence of previous treatment and diagnosis in juvenile dogs presenting with pyrexia to a UK referral centre.

Materials and methods

Clinical records of dogs aged 1 to 18 months presenting with a problem list including pyrexia (??39?2°C) that was reproducible during referral hospitalisation were retrospectively reviewed. Signalment, history - including previous treatment, clinical examination findings and diagnosis were recorded. Diagnoses were categorised as non-infectious inflammatory, infectious, congenital, neoplastic and miscellaneous. The influence of previous treatment on the ability to reach a final diagnosis was analysed.

Results

A total of 140 cases was identified. Diagnosis was reached in 115 cases. Non-infectious inflammatory disease was identified in 91 cases (79%), infectious disease in 19 cases (17%), a congenital disorder in four dogs (3%) and neoplasia in one dog (1%). Breeds most commonly identified were Border collies (17/140; 12%), beagles (16/140; 11%), Labrador retrievers (11/140; 8%), springer spaniels (9/140; 6%) and cocker spaniels (8/140; 6%). Before presentation, most dogs had received antibiotics (83/140; 59%), non-steroidal anti-inflammatory drugs (84/140; 60%) or steroids (9/140; 6%), either alone or in combination. Neither antibiotics nor non-steroidal anti-inflammatory drugs influenced the ability to reach a diagnosis. Steroid-responsive meningitis-arteritis comprised 55 of 91 (60%) individuals of the non-infectious inflammatory cohort. All four dogs diagnosed with congenital disorders were Border collies.

Clinical significance

Non-infectious inflammatory disease, particularly steroid-responsive meningitis-arteritis, immune-mediated polyarthritis and metaphyseal osteopathy, was commonly diagnosed in this population of pyrexic juvenile dogs.

SUBMITTER: Black VL

PROVIDER: S-EPMC7167160 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Publications

Pyrexia in juvenile dogs: a review of 140 referred cases.

Black V L VL Whitworth F J S FJS Adamantos S S

The Journal of small animal practice 20181004 2

<h4>Objectives</h4>To describe the presentation, influence of previous treatment and diagnosis in juvenile dogs presenting with pyrexia to a UK referral centre.<h4>Materials and methods</h4>Clinical records of dogs aged 1 to 18 months presenting with a problem list including pyrexia (≥⃒39∙2°C) that was reproducible during referral hospitalisation were retrospectively reviewed. Signalment, history - including previous treatment, clinical examination findings and diagnosis were recorded. Diagnoses ...[more]

PMID: 30284718

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Project description:Juvenile GM2 gangliosidosis is a group of inherited neurodegenerative diseases caused by deficiency of lysosomal beta-hexosaminidase resulting in GM2 ganglioside accumulation in brain. The purpose of this study was to delineate the natural history of the condition and identify genotype-phenotype correlations that might be helpful in predicting the course of the disease in individual patients.A cohort of 21 patients with juvenile GM2 gangliosidosis, 15 with the Tay-Sachs variant and 6 with the Sandhoff variant, was studied prospectively in 2 centers. Our experience was compared with previously published reports on 134 patients. Information about clinical features, beta-hexosaminidase enzyme activity, and mutation analysis was collected.In our cohort of patients, the mean (+/-SD) age of onset of symptoms was 5.3 +/- 4.1 years, with a mean follow-up time of 8.4 years. The most common symptoms at onset were gait disturbances (66.7%), incoordination (52.4%), speech problems (28.6%), and developmental delay (28.6%). The age of onset of gait disturbances was 7.1 +/- 5.6 years. The mean time for progression to becoming wheelchair-bound was 6.2 +/- 5.5 years. The mean age of onset of speech problems was 7.0 +/- 5.6 years, with a mean time of progression to anarthria of 5.6 +/- 5.3 years. Muscle wasting (10.6 +/- 7.4 years), proximal weakness (11.1 +/- 7.7 years), and incontinence of sphincters (14.6 +/- 9.7 years) appeared later in the course of the disease. Psychiatric disturbances and neuropathy were more prevalent in patients with the Sandhoff variant than in those with the Tay-Sachs variant. However, dysphagia, sphincter incontinence, and sleep problems occurred earlier in those with the Tay-Sachs variant. Cerebellar atrophy was the most common finding on brain MRI (52.9%). The median survival time among the studied and reviewed patients was 14.5 years. The genotype-phenotype correlation revealed that in patients with the Tay-Sachs variant, the presence of R178H and R499H mutations was predictive of an early onset and rapidly progressive course. The presence of either G269S or W474C mutations was associated with a later onset of symptoms along with a more slowly progressive disease course.Juvenile GM2 gangliosidosis is clinically heterogeneous, not only in terms of age of onset and clinical features but also with regard to the course of the disease. In general, the earlier the onset of symptoms, the more rapidly the disease progresses. The Tay-Sachs and Sandhoff variants differed somewhat in the frequency of specific clinical characteristics. Speech deterioration progressed more rapidly than gait abnormalities in both the Tay-Sachs variant and Sandhoff variant groups. Among patients with the Tay-Sachs variant, the HEXA genotype showed a significant correlation with the clinical course.

Dataset Information

Pyrexia in juvenile dogs: a review of 140 referred cases.

Objectives

Materials and methods

Results

Clinical significance

Publications

Pyrexia in juvenile dogs: a review of 140 referred cases.

Similar Datasets

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