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Reduced Production of Bacterial Membrane Vesicles Predicts Mortality in ST45/USA600 Methicillin-Resistant Staphylococcus aureus Bacteremia.

ABSTRACT: Immune biomarkers can stratify mortality risk in staphylococcal bacteremia. Microbial biomarkers may provide more consistent signals during early infection. We demonstrate that in ST45/USA600 bacteremia, bacterial membrane vesicle production in vitro predicts clinical mortality (773 vs. 116 RFU, survivors vs. decedents, p < 0.0001). Using a threshold of 301 relative fluorescence units (RFU), the sensitivity and specificity of the membrane vesicles to predict mortality are 78% and 90%, respectively. This platform is facile, scalable and can be integrated into clinical microbiology lab workflows.

SUBMITTER: Dey S 

PROVIDER: S-EPMC7168145 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Reduced Production of Bacterial Membrane Vesicles Predicts Mortality in ST45/USA600 Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia.

Dey Somrita S   Gudipati Smitha S   Giuliano Christopher C   Zervos Marcus J MJ   Monk Jonathan M JM   Szubin Richard R   Jorgensen Sarah C J SCJ   Sakoulas George G   Berti Andrew D AD  

Antibiotics (Basel, Switzerland) 20191218 1

Immune biomarkers can stratify mortality risk in staphylococcal bacteremia. Microbial biomarkers may provide more consistent signals during early infection. We demonstrate that in ST45/USA600 bacteremia, bacterial membrane vesicle production in vitro predicts clinical mortality (773 vs. 116 RFU, survivors vs. decedents, <i>p</i> < 0.0001). Using a threshold of 301 relative fluorescence units (RFU), the sensitivity and specificity of the membrane vesicles to predict mortality are 78% and 90%, res  ...[more]

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