Unknown

Dataset Information

0

Molecular Diversity of Mytilin-Like Defense Peptides in Mytilidae (Mollusca, Bivalvia).


ABSTRACT: The CS-?? architecture is a structural scaffold shared by a high number of small, cationic, cysteine-rich defense peptides, found in nearly all the major branches of the tree of life. Although several CS-?? peptides involved in innate immune response have been described so far in bivalve mollusks, a clear-cut definition of their molecular diversity is still lacking, leaving the evolutionary relationship among defensins, mytilins, myticins and other structurally similar antimicrobial peptides still unclear. In this study, we performed a comprehensive bioinformatic screening of the genomes and transcriptomes available for marine mussels (Mytilida), redefining the distribution of mytilin-like CS-?? peptides, which in spite of limited primary sequence similarity maintain in all cases a well-conserved backbone, stabilized by four disulfide bonds. Variations in the size of the alpha-helix and the two antiparallel beta strand region, as well as the positioning of the cysteine residues involved in the formation of the C1-C5 disulfide bond might allow a certain degree of structural flexibility, whose functional implications remain to be investigated. The identification of mytilins in Trichomya and Perna spp. revealed that many additional CS-?? AMPs remain to be formally described and functionally characterized in Mytilidae, and suggest that a more robust scheme should be used for the future classification of such peptides with respect with their evolutionary origin.

SUBMITTER: Greco S 

PROVIDER: S-EPMC7168163 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Molecular Diversity of Mytilin-Like Defense Peptides in Mytilidae (Mollusca, Bivalvia).

Greco Samuele S   Gerdol Marco M   Edomi Paolo P   Pallavicini Alberto A  

Antibiotics (Basel, Switzerland) 20200119 1


The CS-αβ architecture is a structural scaffold shared by a high number of small, cationic, cysteine-rich defense peptides, found in nearly all the major branches of the tree of life. Although several CS-αβ peptides involved in innate immune response have been described so far in bivalve mollusks, a clear-cut definition of their molecular diversity is still lacking, leaving the evolutionary relationship among defensins, mytilins, myticins and other structurally similar antimicrobial peptides sti  ...[more]

Similar Datasets

| S-EPMC4549642 | biostudies-other
| S-EPMC10137486 | biostudies-literature
| S-EPMC3271234 | biostudies-literature
| S-EPMC11241113 | biostudies-literature
| S-EPMC2642828 | biostudies-literature
| S-EPMC3890680 | biostudies-literature
| S-EPMC10449738 | biostudies-literature
| S-EPMC7800892 | biostudies-literature
| S-EPMC5096394 | biostudies-literature
| S-EPMC4111485 | biostudies-literature