Ontology highlight
ABSTRACT:
SUBMITTER: Stefanelli VL
PROVIDER: S-EPMC7168757 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Stefanelli Victoria L VL Choudhury Shilpa S Hu Ping P Liu Yining Y Schwenzer Anja A Yeh Chiuan-Ren CR Chambers Dwight M DM von Beck Kelly K Li Wei W Segura Tatiana T Midwood Kim S KS Torres Matthew M Barker Thomas H TH
Matrix biology : journal of the International Society for Matrix Biology 20190417
The extracellular matrix (ECM) microenvironment is increasingly implicated in the instruction of pathologically relevant cell behaviors, from aberrant transdifferentation to invasion and beyond. Indeed, pathologic ECMs possess a panoply of alterations that provide deleterious instructions to resident cells. Here we demonstrate the precise manner in which the ECM protein fibronectin (FN) undergoes the posttranslational modification citrullination in response to peptidyl-arginine deiminase (PAD), ...[more]