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Prostaglandin E-major urinary metabolite versus fecal immunochemical occult blood test as a biomarker for patient with ulcerative colitis.

ABSTRACT: BACKGROUND:Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blood test (FIT). METHODS:PGE-MUM and FIT measurements were performed of 92 urinary and fecal samples obtained from 60 patients with UC. Endoscopic activity was determined by Mayo endoscopic subscore (eMayo) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score. RESULTS:PGE-MUM levels and FIT results showed a significant correlation with respect to eMayo (P?

SUBMITTER: Ishida N 

PROVIDER: S-EPMC7168827 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Prostaglandin E-major urinary metabolite versus fecal immunochemical occult blood test as a biomarker for patient with ulcerative colitis.

Ishida Natsuki N   Miyazu Takahiro T   Takano Ryosuke R   Tamura Satoshi S   Tani Shinya S   Kagami Takuma T   Yamade Mihoko M   Hamaya Yasushi Y   Iwaizumi Moriya M   Osawa Satoshi S   Furuta Takahisa T   Miyajima Hiroaki H   Sugimoto Ken K  

BMC gastroenterology 20200419 1

<h4>Background</h4>Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blood test (FIT).<h4>Methods</h4>PGE-MUM and FIT measurements were performed of 92 urinary and fecal samples obtained from 60 patients with UC. Endoscopic activity was determined by Mayo endoscopic subscore (eMayo) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS)  ...[more]

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