Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans.
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ABSTRACT:
SUBMITTER: Solinski AE
PROVIDER: S-EPMC7169375 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in <i>Streptococcus mutans</i>.
Solinski Amy E AE Scharnow Amber M AM Fraboni Americo J AJ Wuest William M WM
ACS infectious diseases 20190625 8
Understanding the broader biological impact of carolacton, a macrolactone natural product, has been ongoing for the past decade. Multiple studies have shown connections to regulatory systems, acid tolerance mechanisms, biofilm formation, and recently folate dehydrogenase (FolD). Progress elucidating the cause of biofilm-specific activity in <i>Streptococcus mutans</i> has been limited due to low-throughput analyses of carolacton-treated cells. We disclose the discovery of a simplified carolacton ...[more]
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