Common Structural Patterns in the Maxicircle Divergent Region of Trypanosomatidae.
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ABSTRACT:
SUBMITTER: Gerasimov ES
PROVIDER: S-EPMC7169413 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Common Structural Patterns in the Maxicircle Divergent Region of Trypanosomatidae.
Gerasimov Evgeny S ES Zamyatnina Ksenia A KA Matveeva Nadezda S NS Rudenskaya Yulia A YA Kraeva Natalya N Kolesnikov Alexander A AA Yurchenko Vyacheslav V
Pathogens (Basel, Switzerland) 20200205 2
Maxicircles of all kinetoplastid flagellates are functional analogs of mitochondrial genome of other eukaryotes. They consist of two distinct parts, called the coding region and the divergent region (DR). The DR is composed of highly repetitive sequences and, as such, remains the least explored segment of a trypanosomatid genome. It is extremely difficult to sequence and assemble, that is why very few full length maxicircle sequences were available until now. Using PacBio data, we assembled 17 c ...[more]
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