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Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications.

ABSTRACT: Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

SUBMITTER: Rahman HS

PROVIDER: S-EPMC7169473 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications.

Rahman Heshu Sulaiman HS Othman Hemn Hassan HH Hammadi Nahidah Ibrahim NI Yeap Swee Keong SK Amin Kawa Mohammad KM Abdul Samad Nozlena N Alitheen Noorjahan Banu NB

International journal of nanomedicine 20200415

Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made success ...[more]

PMID: 32346289

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Project description:Many technologies ranging from drug delivery approaches to tissue engineering purposes are beginning to benefit from the unique ability of "smart polymers." As a special case, thermo-sensitive hydrogels have great potential, e.g. in actuators, microfluidics, sensors, or drug delivery systems. Here, the loading of Doxorubicin (DOX) with novel thermo-sensitive polymer N-isopropyl acrylamide (PNIPAM) and its copolymers are investigated in order to increase the Doxorubicin's drug efficacy on the targeted tumor site. Therefore, a rational design accurate based on the use of classical molecular dynamics (MD) and well-tempered metadynamics simulations allows for predicting and understanding the behavior of thermo-responsive polymers in the loading of DOX on Hexakis nano-channel at 298 and 320 K. Furthermore, this work investigates the efficacy of this drug carrier for the release of DOX in response to stimuli like variations in temperature and changes in the physiological pH. The study concludes that the Hexakis-polymer composite is capable of adsorbing the DOX at neutral pH and by increasing the temperature of the simulated systems from 298 to 320 K, the strength of intermolecular attraction decreases. In addition, the obtained results of MD simulation revealed that the dominant interaction between DOX and Hexakis in the DOX/polymer/Hexakis systems is the Lennard-Jones (LJ) term due to the formation of strong π-π interaction between the adsorbate and substrate surface. Obtained results show that a higher aggregation of DMA chains around the Hexakis and the formation of stronger bonds with DOX. The results of the well-tempered metadynamics simulations revealed that the order of insertion of drug and polymer into the system is a determining factor on the fate of the adsorption/desorption process. Overall, our results explain the temperature-dependent behavior of the PNIPAM polymers and the suitability of the polymer-Hexakis carrier for Doxorubicin delivery.

Dataset Information

Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications.

Publications

Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications.

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