The bidirectional relationship between CFTR and lipids.
Ontology highlight
ABSTRACT:
SUBMITTER: Cottrill KA
PROVIDER: S-EPMC7170930 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
The bidirectional relationship between CFTR and lipids.
Cottrill Kirsten A KA Farinha Carlos M CM McCarty Nael A NA
Communications biology 20200420 1
Cystic Fibrosis (CF) is the most common life-shortening genetic disease among Caucasians, resulting from mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). While work to understand this protein has resulted in new treatment strategies, it is important to emphasize that CFTR exists within a complex lipid bilayer - a concept largely overlooked when performing structural and functional studies. In this review we discuss cellular lipid imbalances in CF, me ...[more]
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