Ontology highlight
ABSTRACT:
SUBMITTER: Nilsen J
PROVIDER: S-EPMC7171077 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nilsen Jeannette J Trabjerg Esben E Grevys Algirdas A Azevedo Claudia C Brennan Stephen O SO Stensland Maria M Wilson John J Sand Kine Marita Knudsen KMK Bern Malin M Dalhus Bjørn B Roopenian Derry C DC Sandlie Inger I Rand Kasper Dyrberg KD Andersen Jan Terje JT
Communications biology 20200420 1
Albumin has an average plasma half-life of three weeks and is thus an attractive carrier to improve the pharmacokinetics of fused therapeutics. The half-life is regulated by FcRn, a cellular receptor that protects against intracellular degradation. To tailor-design the therapeutic use of albumin, it is crucial to understand how structural alterations in albumin affect FcRn binding and transport properties. In the blood, the last C-terminal residue (L585) of albumin may be enzymatically cleaved. ...[more]