Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study.
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ABSTRACT:
SUBMITTER: Hu F
PROVIDER: S-EPMC7171100 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study.
Hu Fanlei F Jiang Xiang X Guo Chunqing C Li Yingni Y Chen Shixian S Zhang Wei W Du Yan Y Wang Ping P Zheng Xi X Fang Xiangyu X Li Xin X Song Jing J Xie Yang Y Huang Fei F Xue Jimeng J Bai Mingxin M Jia Yuan Y Liu Xu X Ren Limin L Zhang Xiaoying X Guo Jianping J Pan Hudan H Su Yin Y Yi Huanfa H Ye Hua H Zuo Daming D Li Juan J Wu Huaxiang H Wang Yongfu Y Li Ru R Liu Liang L Wang Xiang-Yang XY Li Zhanguo Z
Nature communications 20200420 1
Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and compleme ...[more]
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