Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma.
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ABSTRACT:
SUBMITTER: Ngan HL
PROVIDER: S-EPMC7171136 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Erlotinib sensitivity of <i>MAPK1</i>p.D321N mutation in head and neck squamous cell carcinoma.
Ngan Hoi-Lam HL Poon Peony Hiu Yan PHY Su Yu-Xiong YX Chan Jason Ying Kuen JYK Lo Kwok-Wai KW Yeung Chun Kit CK Liu Yuchen Y Wong Eileen E Li Hui H Lau Chin Wang CW Piao Wenying W Lui Vivian Wai Yan VWY
NPJ genomic medicine 20200420 1
Head and neck squamous cell carcinoma (HNSCC) lacks predictive biomarkers for drug responses. By targeted sequencing, we identified two <i>MAPK1</i> mutations in recurrent HNSCC, <i>MAPK1</i>p.D321N, and p.R135K. We previously reported an exceptional erlotinib responder with <i>MAPK1</i>p.E322K. Here, by in silico and drug studies, we determined functions of these two recurrence-associated <i>MAPK1</i> mutations. Residues D321, R135, and E322 are in 3D proximity. <i>MAPK1</i>p.D321N drives marke ...[more]
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