Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC7171144 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Xu Jianquan J Ma Hongqiang H Ma Hongbin H Jiang Wei W Mela Christopher A CA Duan Meihan M Zhao Shimei S Gao Chenxi C Hahm Eun-Ryeong ER Lardo Santana M SM Troy Kris K Sun Ming M Pai Reet R Stolz Donna B DB Zhang Lin L Singh Shivendra S Brand Randall E RE Hartman Douglas J DJ Hu Jing J Hainer Sarah J SJ Liu Yang Y
Nature communications 20200420 1
Genomic DNA is folded into a higher-order structure that regulates transcription and maintains genomic stability. Although progress has been made on understanding biochemical characteristics of epigenetic modifications in cancer, the in-situ higher-order folding of chromatin structure during malignant transformation remains largely unknown. Here, using optimized stochastic optical reconstruction microscopy (STORM) for pathological tissue (PathSTORM), we uncover a gradual decompaction and fragmen ...[more]