Ontology highlight
ABSTRACT:
SUBMITTER: Dudenhoeffer BR
PROVIDER: S-EPMC7171158 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Dudenhoeffer Benjamin R BR Borggraefe Jan J Schweimer Kristian K Knauer Stefan H SH
Scientific reports 20200420 1
Antitermination (AT) is a ubiquitous principle in the regulation of bacterial transcription to suppress termination signals. In phage λ antiterminator protein Q controls the expression of the phage's late genes with loading of λQ onto the transcription elongation complex halted at a σ-dependent pause requiring a specific DNA element. The molecular basis of λQ-dependent AT and its dependence on N-utilization substance (Nus) A is so far only poorly understood. Here we used solution-state nuclear m ...[more]