Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC7171250 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Infection and immunity 20200420 5
Gamma interferon (IFN-γ)-induced innate immune responses play important roles in the inhibition of <i>Toxoplasma gondii</i> infection. It has been reported that IFN-γ stimulates non-acidification-dependent growth restriction of <i>T. gondii</i> in HeLa cells, but the mechanism remains unclear. Here, we found that γ-aminobutyric acid (GABA) receptor-associated protein-like 2 (GABARAPL2) plays a critical role in parasite restriction in IFN-γ-treated HeLa cells. GABARAPL2 is recruited to membrane s ...[more]