Ontology highlight
ABSTRACT:
SUBMITTER: Tang S
PROVIDER: S-EPMC7171400 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Tang Shangkun S Zhou Weijun W Zhong Xinyang X Xu Jianchen J Huang Huasong H Zheng Xinnan X Zhang Jingkang J Yang Shuyue S Shang Ping P Tang Qian Q Liu Haixiao H
Journal of cellular and molecular medicine 20200224 7
Osteoarthritis (OA), which is principally featured by progressive joint metabolic imbalance and subsequent degeneration of articular cartilage, is a common chronic joint disease. Arctigenin (ATG), a dietary phyto-oestrogen, has been described to have potent anti-inflammatory effects. Nevertheless, its protective effects on OA have not been clearly established. The target of our following study is to evaluate the protective effects of ATG on IL-1β-induced human OA chondrocytes and mouse OA model. ...[more]