Ontology highlight
ABSTRACT:
SUBMITTER: Bardelli D
PROVIDER: S-EPMC7171411 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Bardelli Donatella D Sassone Francesca F Colombrita Claudia C Volpe Clara C Gumina Valentina V Peverelli Silvia S Catusi Ilaria I Ratti Antonia A Silani Vincenzo V Bossolasco Patrizia P
Journal of cellular and molecular medicine 20200303 7
As for the majority of neurodegenerative diseases, pathological mechanisms of amyotrophic lateral sclerosis (ALS) have been challenging to study due to the difficult access to alive patients' cells. Induced pluripotent stem cells (iPSCs) offer a useful in vitro system for modelling human diseases. iPSCs can be theoretically obtained by reprogramming any somatic tissue although fibroblasts (FB) remain the most used cells. However, reprogramming peripheral blood cells (PB) may offer significant ad ...[more]