Using arterial-venous oxygen difference to guide red blood cell transfusion strategy.

ABSTRACT:

Background

Guidelines recommend a restrictive red blood cell transfusion strategy based on hemoglobin (Hb) concentrations in critically ill patients. We hypothesized that the arterial-venous oxygen difference (A-V O_2diff), a surrogate for the oxygen delivery to consumption ratio, could provide a more personalized approach to identify patients who may benefit from transfusion.

Methods

A prospective observational study including 177 non-bleeding adult patients with a Hb concentration of 7.0-10.0 g/dL within 72 h after ICU admission. The A-V O_2diff, central venous oxygen saturation (ScvO₂), and oxygen extraction ratio (O₂ER) were noted when a patient's Hb was first within this range. Transfusion decisions were made by the treating phy

SUBMITTER: Fogagnolo A 

PROVIDER: S-EPMC7171832 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature