Ontology highlight
ABSTRACT:
SUBMITTER: Subbiah V
PROVIDER: S-EPMC7171918 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Subbiah Vivek V Dumbrava Ecaterina Ileana EI Jiang Yunfang Y Thein Kyaw Z KZ Naing Aung A Hong David S DS Fu Siqing S Piha-Paul Sarina A SA Tsimberidou Apostolia M AM Janku Filip F Meric-Bernstam Funda F Kurzrock Razelle R Falchook Gerald G
Experimental hematology & oncology 20200420
<h4>Background</h4>Angiogenesis and activation of the epidermal growth factor (EGFR) pathway play an essential role in tumor proliferation and metastasis. Targeting angiogenesis or EGFR alone does not yield adequate tumor control in most solid tumors. Overcoming intrinsic and/or acquired resistance may need a doublet or triplet therapy strategy. Herein, we report the safety and feasibility of dual EGFR blockade with EGFR monoclonal antibody and EGFR tyrosine kinase inhibitor combined with anti-V ...[more]