Ontology highlight
ABSTRACT:
SUBMITTER: Baltina LA
PROVIDER: S-EPMC7172207 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Baltina Lidia A LA Tasi Yan-Ting YT Huang Su-Hua SH Lai Hsueh-Chou HC Baltina Lia A LA Petrova Svetlana F SF Yunusov Marat S MS Lin Cheng-Wen CW
Bioorganic & medicinal chemistry letters 20190829 20
Dengue virus (DENV) is one of the most geographically distributed pathogenic flaviviruses transmitted by mosquitoes Aedes sps. In this study, the structure-antiviral activity relationships of Glycyrrhizic acid (GL) derivatives was evaluated by the inhibitory assays on the cytopathic effect (CPE) and viral infectivity of DENV type 2 (DENV2) in Vero E6 cells. GL (96% purity) had a low cytotoxicity to Vero E6 cells, inhibited DENV2-induced CPE, and reduced the DENV-2 infectivity with the IC50 of 8. ...[more]