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A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children.

ABSTRACT: BACKGROUND:Recently, Allander and co-workers reported the discovery of a new human polyomavirus, KI virus, in respiratory secretions from patients with acute respiratory tract infection (ARTI). OBJECTIVE:We examined 951 respiratory samples collected in Queensland, Australia, between November 2002 and August 2003 from patients with respiratory infection, for the presence of the KI virus. RESULTS:Twenty-four (2.5%) samples were positive for KI virus with 20 (83%) of these from children younger than 5 years. In six (25%) patients KI was co-detected with another virus. Full genome sequencing of three isolates shows a high degree of conservation between the Queensland isolates and the original isolates reported from Swedish patients. CONCLUSIONS:The newly described KI polyomavirus may commonly be found in the respiratory tract of patients with ARTI, particularly children, and results indicate that the virus has global presence.

SUBMITTER: Bialasiewicz S

PROVIDER: S-EPMC7172449 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature

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A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children.

Bialasiewicz Seweryn S Whiley David M DM Lambert Stephen B SB Wang David D Nissen Michael D MD Sloots Theo P TP

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20070813 1

<h4>Background</h4>Recently, Allander and co-workers reported the discovery of a new human polyomavirus, KI virus, in respiratory secretions from patients with acute respiratory tract infection (ARTI).<h4>Objective</h4>We examined 951 respiratory samples collected in Queensland, Australia, between November 2002 and August 2003 from patients with respiratory infection, for the presence of the KI virus.<h4>Results</h4>Twenty-four (2.5%) samples were positive for KI virus with 20 (83%) of these fro ...[more]

PMID: 17706457

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Project description:OBJECTIVE:To investigate the relationship of KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV) with acute respiratory infection in children in Tianjin, China. METHODS:A total of 3?730 nasopharyngeal secretions were collected from hospitalized children with acute respiratory infection in Tianjin Children's Hospital from January 2011 to December 2013. Viral nucleic acid was extracted, and virus infection (KIPyV and WUPyV) was determined by PCR. Some KIPyV-positive and WUPyV-positive PCR products were subjected to sequencing. Sequencing results were aligned with the known gene sequences of KIPyV and WUPyV to construct a phylogenetic tree. Amplified VP1 fragments of KIPyV were inserted into the cloning vector (PUCm-T) transformed into E.?coli competent cells. Positive clones were identified by PCR and sequencing. The nucleotide sequences were submitted to GenBank. In addition, another seven common respiratory viruses in all samples were detected by direct immunofluorescence assay. RESULTS:In the 3?730 specimens, the KIPyV-positive rate was 12.14% (453/3?730) and the WUPyV-positive rate was 1.69% (63/3?730). The mean infection rate of KIPyV was significantly higher in June and July, while the mean infection rate of WUPyV peaked in February and March. Most of the KIPyV-positive or WUPyV-positive children were <3 years. The co-infections with KIPyV, WUPyV, and other respiratory viruses were observed in the children. The co-infection rate was 2.31% (86/3?730) and there were nine cases of co-infections with WUPyV and KIPyV. Thirty-five KIPyV-positive and twelve WUPyV-positive PCR products were sequenced and the alignment analysis showed that they had high homology with the known sequences (94%-100% vs 95%-100%). The VP1 gene sequences obtained from two KIPyV strains in this study were recorded in GenBank with the accession numbers of KY465925 and KY465926. CONCLUSIONS:For some children with acute respiratory infection in Tianjin, China, the acute respiratory infection may be associated with KIPyV and WUPyV infections. KIPyV infection is common in summer, and WUPyV infection in spring. The epidemic strains in Tianjin have a high homology with those in other regions.

Dataset Information

A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children.

Publications

A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children.

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