Ontology highlight
ABSTRACT:
SUBMITTER: Sandekian V
PROVIDER: S-EPMC7172830 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Virology 20150515
In the last few years, the development of a plasmid-based reverse genetics system for mammalian reovirus has allowed the production and characterization of mutant viruses. This could be especially significant in the optimization of reovirus strains for virotherapeutic applications, either as gene vectors or oncolytic viruses. The genome of a mutant virus exhibiting increased sensitivity to interferon was completely sequenced and compared with its parental virus. Viruses corresponding to either t ...[more]