Ontology highlight
ABSTRACT:
SUBMITTER: Parackova Z
PROVIDER: S-EPMC7172866 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Parackova Zuzana Z Zentsova Irena I Vrabcova Petra P Klocperk Adam A Sumnik Zdenek Z Pruhova Stepanka S Petruzelkova Lenka L Hasler Robert R Sediva Anna A
Frontiers in immunology 20200414
Neutrophils releasing neutrophil extracellular traps (NETs) infiltrate the pancreas prior to type 1 diabetes (T1D) onset; however, the precise nature of their contribution to disease remains poorly defined. To examine how NETs affect immune functions in T1D, we investigated NET composition and their effect on dendritic cells (DCs) and T lymphocytes in T1D children. We showed that T1D patient NET composition differs substantially from that of healthy donors and that the presence of T1D-NETs in a ...[more]