Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC7173406 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Li Jinyang J Yuan Salina S Norgard Robert J RJ Yan Fangxue F Yamazoe Taiji T Blanco Andrés A Stanger Ben Z BZ
Cancer immunology research 20191223 3
Although immune checkpoint blockade (ICB) improves clinical outcome in several types of malignancies, pancreatic ductal adenocarcinoma (PDA) remains refractory to this therapy. Preclinical studies have demonstrated that the relative abundance of suppressive myeloid cells versus cytotoxic T cells determines the efficacy of combination immunotherapies, which include ICB. Here, we evaluated the role of the ubiquitin-specific protease 22 (USP22) as a regulator of the immune tumor microenvironment (T ...[more]