Photoacoustic imaging to localize indeterminate pulmonary nodules: A preclinical study.

ABSTRACT:

Purpose

Diagnosis and resection of indeterminate pulmonary nodules (IPNs) is a growing challenge with increased utilization of chest computed tomography. Photoacoustic (PA) -guided surgical resection with local injection of indocyanine green (ICG) may have utility for IPNs that are suspicious for lung cancer. This preclinical study explores the potential of PA imaging (PAI) to detect ICG-labeled tumors.

Materials and methods

ICG uptake by H460 lung cancer cells was evaluated in vitro. A phantom study was performed to analyze PA signal intensity according to ICG concentration and tissue thickness/depth using chicken breast. PA signals were measured up to 48 hours after injection of ICG (mixed with 5% agar) into healthy subcutaneous tissue, subcutaneous H460 tumors and right h

SUBMITTER: Lee CY 

PROVIDER: S-EPMC7173852 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature